HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-nitrobenzaldehyde → 4-chloro-2-(4-trimethylsilanyl-but-3-ynyl)-2H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-nitrobenzaldehyde | HCID 80701 | — |
| Reactant | (4-Aminobut-1-yn-1-yl)trimethylsilane | HCID 19703099 | — |
| Product | 4-chloro-2-(4-trimethylsilanyl-but-3-ynyl)-2H-indazole | HCID 66597993 | 43% |
Reaction Steps
The title compound was prepared in accordance with the general method of Example 149(A), for 2-chloro-6-nitro-benzaldehyde (210 mg, 1.13 mmol) and 4-trimethylsilanyl-but-3-ynylamine (210 mg, 1.50 mmol). The crude product was purified by flash chromatography (cyclohexane/AcOEt 92.5:7.5) to yield 4-chloro-2-(4-trimethylsilanyl-but-3-ynyl)-2H-indazole (134 mg, 0.48 mmol, 43%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101637B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ca72907645fa43ffb1677373a0453631 |
| Source note | uspto-grants-2012_01 |