3-(1-chlorophthalazin-6-yl)-N-cyclopropyl-4-methylbenzamide → 3-(1-(5-chloro-2-methyl-4-(methylsulfonyl)phenyl)phthalazin-6-yl)-N-cyclopropyl-4-methylbenzamide

HRID 422563Notes

Reaction equation

HRID 422563 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:13]=[C:14]([CH:21]=[CH:22][C:23]=3[CH3:24])[C:15]([NH:17][CH:18]3[CH2:20][CH2:19]3)=[O:16])=[CH:9][CH:10]=2)[CH:5]=[N:4][N:3]=1.[Cl:25][C:26]1[C:27]([S:42]([CH3:45])(=[O:44])=[O:43])=[CH:28][C:29]([CH3:41])=[C:30](B2OC(C)(C)C(C)(C)O2)[CH:31]=1>>[Cl:25][C:26]1[C:27]([S:42]([CH3:45])(=[O:43])=[O:44])=[CH:28][C:29]([CH3:41])=[C:30]([C:2]2[C:11]3[C:6](=[CH:7][C:8]([C:12]4[CH:13]=[C:14]([CH:21]=[CH:22][C:23]=4[CH3:24])[C:15]([NH:17][CH:18]4[CH2:19][CH2:20]4)=[O:16])=[CH:9][CH:10]=3)[CH:5]=[N:4][N:3]=2)[CH:31]=1

Participants

3

Reactant 2

HCID 118483123-(1-chlorophthalazin-6-yl)-N-cyclopropyl-4-methylbenzamideHCID 666746652-(5-Chloro-2-methyl-4-(methylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 597260113-(1-(5-chloro-2-methyl-4-(methylsulfonyl)phenyl)phthalazin-6-yl)-N-cyclopropyl-4-methylbenzamide

Procedure

This material was prepared according to the procedure similar to that described in Method A-Example 3a, using 3-(1-chlorophthalazin-6-yl)-N-cyclopropyl-4-methylbenzamide and 2-(5-chloro-2-methyl-4-(methylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI, pos. ion) m/z: 506.9 (M+1).

Workup

  1. customThis material was prepared

Sources & evidence

ORD record
ord-b603ce9e5ca649f58ade970f83d353f8
Source dataset
uspto-grants-2012_01
Patent number
US08101612B2

Reaction notes

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