Potassium Phosphate, Tribasic → HCID 24855712, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-chloro-1-(1-(trifluoromethyl)cyclopropyl)phthalazine (20 mg, 73 mmol), N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (27 mg, 88 μmol), Pd2(dba)3 (2.0 mg, 2.2 μmol), potassium phosphate (47 mg, 220 μmol) and X-Phos (2.0 mg) in 1.0 mL of dioxane and 0.5 mL water in a sealed glass tube was heated in a microwave for 20 min at 135° C. The mixture was partitioned between 1.0 N NaOH (1.0 mL) and EtOAc (5.0 mL). The organic layer was separated, dried and concentrated. Purification on an ISCO (4.0 g column, 60-100% EtOAc:Hexanes) provided the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 412.1 (M+1).

Provenance & Evidence