HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → 4-Methyl-3-(1-(1,1,1-trifluoropropan-2-yloxy)phthalazin-6-yl)benzenamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | HCID 16086089 | — |
| Reactant | Phthalazine, 6-chloro-1-(2,2,2-trifluoro-1-methylethoxy)- | HCID 66675982 | — |
| Product | 4-Methyl-3-(1-(1,1,1-trifluoropropan-2-yloxy)phthalazin-6-yl)benzenamine | HCID 66675739 | — |
Reaction Steps
The title compound was prepared according to a procedure similar to that described in Example 225, using 6-chloro-1-(1,1,1-trifluoropropan-2-yloxy)phthalazine and 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine as starting materials. MS (ESI, pos. ion) m/z: 348.1 (M+1). The racemic material was subjected to Preparative SFC separation using a chiral column to afford its (R)- and (S)-enantiomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101612B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-e31646723b8647f9bac97b0a8f9b1c35 |
| Source note | uspto-grants-2012_01 |