HCID 66674804, compound → HCID 59726023, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-(5-iodo-2-methylphenyl)-1-((R)-1,1,1-trifluoropropan-2-yloxy)phthalazine (100 mg, 0.22 mmol) and copper cyanide (98 mg, 1.09 mmol) in 1.0 mL of DMF in a sealed glass tube was heated at 120° C. in a microwave synthesizer for 20 min. The cooled reaction was diluted with CH2Cl2 and washed with water and brine. The organic layer was dried (MgSO4), filtered, and concentrated. Purification on a silica gel column (20-50% of EtOAc in Hexanes) afforded 4-methyl-3-(1-((R)-1,1,1-trifluoropropan-2-yloxy)phthalazin-6-yl)benzonitrile as a white solid. MS (ESI, pos. ion) m/z: 358.4 (M+1).

Provenance & Evidence