HCID 66675967, compound → HCID 59726021, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-(6-chlorophthalazin-1-yl)ethanone (350 mg, 1.69 mmol) in 20 mL of THF at 0° C. was treated with 0.8 mL MeMgBr (3.16 M in Et2O) and stirred at 0° C. for 1 h. The mixture was quenched with saturated NH4Cl, and extracted 2×20 mL EtOAc. The combined EtOAc layers were dried over MgSO4, filtered and concentrated. Purification on an ISCO (12 g column, 15-50% EtOAc:Hexanes) afforded 2-(6-chlorophthalazin-1-yl)propan-2-ol (172 mg, 46% yield) as a pale yellow amorphous solid. MS (ESI, pos. ion) m/z: 223.1 (M+1).

Provenance & Evidence