HCID 57826941, compound → HCID 12468202, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 4-(2-methoxy-2-oxoethyl)-2,5-dimethyl-6H-thieno[2,3-b]pyrrole-6-carboxylate (0.790 g, 2.443 mmol) in DCM (13.13 mL) was added 13 mL of silica gel. The mixture was concentrated under reduced pressure and the residue was heated to 65° C. under vacuum for 24 h. The reaction mixture was purified by flash chromatography on silica gel (EtOAc/heptane 15/85), to give the title compound (0.35 g, 64%): LC/MS (Table 1, Method a) Rt=2.06 min; MS m/z 222.1 (M−H)−.

Provenance & Evidence