HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-(2-(Vinyloxy)ethyl)hydroxylamine → 2-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (2-hydroxyethoxy)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-(2-(Vinyloxy)ethyl)hydroxylamine | HCID 21867017 | — |
| Reactant | 2-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid | HCID 57636936 | — |
| Reactant | 2-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (2-vinyloxyethoxy)-amide | HCID 86672323 | — |
| Product | 2-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (2-hydroxyethoxy)-amide | HCID 11234968 | 60% |
Reaction Steps
Preparation of 2-(4-bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (2-vinyloxyethoxy)-amide: 2-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (0.020 g, 0.059 mmol) was coupled as described previously in Example 154 using O-(2-vinyloxy-ethyl)-hydroxylamine to yield 0.015 g (60%) pure desired product as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101639B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-4edd6954302e4f11b9d3b35891bf78bb |
| Source note | uspto-grants-2012_01 |