反应详情

To a mixture of 3-indolepropionic acid (4.00 g, 1 eq) in ethanol (70 ml), 1 ml of sulphuric acid is added dropwise and the mixture is first refluxed overnight and then evaporated to dryness. The resulting crude residue is dissolved in ethyl acetate and the organic solution is washed with 5% aqueous sodium bicarbonate, water, dried over MgSO4, filtered and finally evaporated to dryness, to afford the title compound as a yellow solid (4.30 g, 95% yield), which is used as such for the next step.

1. additionis added dropwise
2. temperaturethe mixture is first refluxed overnight
3. customevaporated to dryness
4. dissolutionThe resulting crude residue is dissolved in ethyl acetate
5. washthe organic solution is washed with 5% aqueous sodium bicarbonate, water
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customfinally evaporated to dryness