HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzaldehyde → N-[(E)-(4-fluorophenyl)methylideneamino]-3-(1H-indol-3-yl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | 3-Indolepropionic acid hydrazide | HCID 230580 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-[(E)-(4-fluorophenyl)methylideneamino]-3-(1H-indol-3-yl)propanamide | HCID 42601449 | 98.7% |
Reaction Steps
A solution of 3-(1H-Indol-3-yl)-propionic acid hydrazide (0.300 g, 1 eq) and 4-fluorobenzaldehyde (0.183 g, 1 eq) in toluene (7 ml) is refluxed overnight and then evaporated to dryness, to afford 0.450 g of white product that is purified by flash chromatography using neutral alumina and eluting with 1% methanol in chloroform (0.269 g, 59% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101649B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-b1cea9f23e8b4d72ba28f470c4a15f55 |
| Source note | uspto-grants-2012_01 |