Hydrochloric Acid → HCID 178454174, compound

Participants

Reaction Steps

Boc-hArg(NO2)-Amp (1.5 g) was dissolved in HPLC grade MeOH (120 mL) and to the clear solution was added the Pd/C catalyst (10%, Aldrich). A small stir bar was placed in the flask and the reaction mixture was stirred under a slow stream of hydrogen overnight after incorporating the 5-6 N HCl in 2-propanol solution (1.5 mL). After the overnight reaction, the solution was filtered and the solvent evaporated. The white crystalline product was dried under vacuum to give 1.61 g of the Boc-hArg-Amp intermediate product.

Provenance & Evidence