3-Bromo-α-methylenebenzenepropanoic acid → HCID 10881645, compound

Participants

Reaction Conditions

Reaction Steps

To a 5 ml pear-shaped flask containing 2-(3-bromobenzyl)acrylic acid (0.44 g, 1.83 mmol) was added thioacetic acid (1 ml, 1.065 g, 13.99 mmol). The mixture was heated at 50° C. for 2.5 hours, after which excess thioacetic acid was removed under reduced pressure. The residue was co-evaporated with toluene twice, then purified via silica gel column chromatography eluting with 0 to 2% MeOH in CH2Cl2, giving 2-(acetylsulfanylmethyl)-3-(3-bromophenyl)propionic acid as a colorless glue, 0.55 g, 95% yield, HPLC purity: 96.9%.

Provenance & Evidence