HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 423121Generated: October 29, 2026
Hydrochloric Acid → 3-Amino-3-(4-chlorophenyl)propanenitrile
https://huagongshe.com/reaction/423121
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Tert-butyl 1-(4-chlorophenyl)-2-cyanoethylcarbamate | HCID 57750327 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Amino-3-(4-chlorophenyl)propanenitrile | HCID 55283354 | 120.1% |
Reaction Steps
HCl (4M) in 1,4-dioxane (0.668 mL, 2.67 mmol) was added in one portion to tert-butyl 1-(4-chlorophenyl)-2-cyanoethylcarbamate (Intermediate 24) (150 mg, 0.53 mmol) in DCM (4 mL) at 20° C. The resulting solution was stirred at 20° C. for 18 hours. The reaction mixture was evaporated to afford 3-amino-3-(4-chlorophenyl)propanenitrile (HCl salt) (115 mg, 99%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08101623B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-b503fb5ad59e4b16b9e907c777db0026 |
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| Source note | uspto-grants-2012_01 |
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