HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methanesulfonic acid 6-methyl-pyridin-3-ylmethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (6-Methylpyridin-3-yl)methanol | HCID 11228788 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methanesulfonic acid 6-methyl-pyridin-3-ylmethyl ester | HCID 58278804 | — |
Reaction Steps
To a solution of (6-Methyl-pyridin-3-yl)-methanol (24.36 kg, 198 mol) dissolved in tetrahydrofuran (80 kg) under nitrogen at −3° C. was added triethylamine (22.14 kg, 218.8 mol) over 30 mins followed by methanesulphonyl chloride (23.16 kg, 202.2 mol) over 3 hr and the slurry stirred for an additional 30 mins. The slurry was then filtered to remove triethylamine hydrochloride and the cake washed four times with tetraydrofuran (21.6 kg). An aliquot was removed and concentrated and analysed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101750B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-8efbf6aca8164368b82e4dc1a0fd284a |
| Source note | uspto-grants-2012_01 |