Hydrochloric Acid → HCID 66674206, compound

Participants

Reaction Conditions

Reaction Steps

To the (5-Cyano-2-nitro-phenyl)-(5-morpholin-4-ylmethyl-pyridin-2-yl)-acetic acid ethyl ester solution in n-butylacetate (92 ml; Example 8) was added ethanol (235.3 ml) followed by n-butylacetate (117.7 ml) and the solution was heated to 60° C. Seed (0.1 g) was added to the hot solution followed by a solution of hydrochloric acid in isopropanol (13.44 ml, 4.68M, 62.9 mol) and the solution cooled to −10° C. over 10 hrs. The crystals were filtered and washed twice with ethanol (20 ml). After drying at 40° C. under vacuum gave 21.46 g, 79% yield of (5-Cyano-2-nitro-phenyl)-(5-morpholin-4-ylmethyl-pyridin-2-yl)-acetic acid ethyl ester hydrochloride salt as red wine crystals. Characterisation data were in accordance with example 7.

Provenance & Evidence