HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Butyn-1-ol → 4-(2-Butynyloxy)-5,6-difluoropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Butyn-1-ol | HCID 12991 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4,5,6-Trifluoropyrimidine | HCID 3572764 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 4-(2-Butynyloxy)-5,6-difluoropyrimidine | HCID 59661966 | 80.1% |
Reaction Steps
0.5 g of 4,5,6-trifluoropyrimidine, 0.31 g of 2-butyn-1-ol and 0.62 ml of N,N-diisopropylethylamine were added to 1 ml of hexane, then the mixture was stirred at room temperature for 1 hour. Then the reaction mixture was subjected to silica gel column chromatography to obtain 0.55 g of 4-(2-butynyloxy)-5,6-difluoropyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101753B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-0881306c4e544e539e7ca8592d823197 |
| Source note | uspto-grants-2012_01 |