HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 4-(2-Butynyloxy)-5-fluoro-6-pyrrolidinopyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-(2-Butynyloxy)-5,6-difluoropyrimidine | HCID 59661966 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(2-Butynyloxy)-5-fluoro-6-pyrrolidinopyrimidine | HCID 11630037 | 74.4% |
Reaction Steps
0.2 g of 4-(2-butynyloxy)-5,6-difluoropyrimidine and 0.09 g of pyrrolidine were added to 0.3 ml of toluene, then the mixture was stirred at room temperature for 3 hours. Then the reaction mixture was subjected to silica gel column chromatography to obtain 0.19 g of 4-(2-butynyloxy)-5-fluoro-6-pyrrolidinopyrimidine (referred as the present compound (1) hereinafter).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101753B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-4c41b99270484c859bff3d801a5f7f47 |
| Source note | uspto-grants-2012_01 |