Pyrrolidine → 5-Fluoro-4-(2-pentynyloxy)-6-pyrrolidinopyrimidine

Participants

Reaction Steps

0.1 g of 4,5-difluoro-6-(2-pentynyloxy)pyrimidine and 0.04 g of pyrrolidine were added to 0.2 ml of toluene, then the reaction mixture was stirred at room temperature for 3 hours. Then the reaction mixture was subjected to silica gel column chromatography to obtain 0.11 g of 5-fluoro-4-(2-pentynyloxy)-6-pyrrolidinopyrimidine (referred as the present compound (5) hereinafter).

Provenance & Evidence