HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)piperidine → 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)piperidine | HCID 2760776 | — |
| Reactant | 4-(2-Butynyloxy)-6-fluoropyrimidine | HCID 59661969 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine | HCID 57672951 | — |
Reaction Steps
0.2 g of 4-(2-butynyloxy)-6-fluoropyrimidine and 0.15 g of 3-trifluoromethylpiperidine are added to 1 ml of toluene, then the mixture is stirred at room temperature for 30 minutes. Then the reaction mixture is subjected to silica gel column chromatography to obtain 4-(2-butynyloxy)-6-(3-trifluoromethylpyperidino)pyrimidine (referred as the present compound (10) hereinafter).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101753B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-396961e1920d455cb9aea8f8df2fdd63 |
| Source note | uspto-grants-2012_01 |