HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 178491319, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 3-Fluorobenzaldehyde | HCID 68009 | — |
| Reactant | methyl 4-(4-methoxyphenyl)-2,4-dioxobutanoate | HCID 308121 | — |
| Reactant | 4-(1,2-Oxazol-3-yl)aniline | HCID 23118576 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 178491319 | HCID 178491319 | 34% |
Reaction Steps
To a mixture of methyl (4-methoxybenzoyl)pyruvate (0.24 g, 1 mmol) and 4-isoxazol-3-ylaniline (0.16 g, 1 mmol) in dioxane (1 mL) was added 3-fluorobenzaldehyde (0.11 mL, 1 mmol). The mixture was stirred at r.t. for two days. Diethyl ether (3 mL) was then added to the mixture, and the precipitate was collected by filtration to give 5-(3-fluorophenyl)-3-hydroxy-1-(4-isoxazol-3-ylphenyl)-4-(4-methoxybenzoyl)-1,5-dihydropyrrol-2-one (0.16 g, 34%) as slightly yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101644B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-282121cb74ed4ad1b2536a0124ceb838 |
| Source note | uspto-grants-2012_01 |