反应详情

To a solution of 4-hydroxy-3-trifluoromethylbenzoic acid (395 mg) in methanol (5 mL) was added conc. sulfuric acid (0.4 mL), and the mixture was heated for 6 hours under reflux. The reaction mixture was allowed to stand for cooling down to room temperature, and concentrated in vacuo. The residue was diluted with ethyl acetate, washed with water and saturated brine, and concentrated to give the title compound (403 mg).

1. temperaturethe mixture was heated for 6 hours
2. temperatureunder reflux
3. concentrationconcentrated in vacuo
4. additionThe residue was diluted with ethyl acetate
5. washwashed with water and saturated brine
6. concentrationconcentrated