Hydrochloric Acid → HCID 58629735, compound

Participants

Reaction Steps

To a solution of 3-ethoxy-4-hydroxy-5-methoxybenzaldehyde (578 mg), sodium dihydrogenphosphate (1.41 g), and amidosulfuric acid (429 mg) in dioxane (6 mL)-water (10 mL) was added an aqueous solution (3 mL) of sodium chlorite (400 mg) under ice-cooling. The mixture was stirred for 2 hours under ice-cooling. Hydrochloric acid was added thereto, and the reaction mixture was extracted with ethyl acetate. The extract was washed with 10% aqueous sodium thiosulfate and saturated brine, dried over anhydrous sodium sulfate, and concentrated to give the title compound (586 mg).

Provenance & Evidence