HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-(2-Isopropyl-2H-tetrazol-5-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 5-(4-Benzyloxyphenyl)-2-isopropyl-2H-tetrazole | HCID 58629782 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(2-Isopropyl-2H-tetrazol-5-yl)phenol | HCID 135974450 | 97.4% |
Reaction Steps
To a solution of 5-(4-benzyloxyphenyl)-2-isopropyl-2H-tetrazole (521 mg) in THF (5 mL)-methanol (5 mL) was added 7.5% palladium-carbon (60 mg). The mixture was stirred at room temperature for 3.5 hours under hydrogen atmosphere. The catalyst was filtered off through a Celite pad. The filtrate was concentrated to give the title compound (352 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101774B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-6ddd3fc3e4804fafb26da83c40ae47b8 |
| Source note | uspto-grants-2012_01 |