4-Methoxycarbonylphenylboronic acid → HCID 58629762, compound

HRID 423258Notes

Reaction equation

HRID 423258 reaction equation
[CH2:1]([O:8][C:9](=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[N:12][C:11]=1Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:19][O:20][C:21]([C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1)=[O:22]>>[CH2:1]([O:8][C:9](=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[N:12][C:11]=1[C:26]1[CH:27]=[CH:28][C:23]([C:21]([O:20][CH3:19])=[O:22])=[CH:24][CH:25]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27343694-Methoxycarbonylphenylboronic acidHCID 58629765Benzyl 2-chloro-6-methylpyridine-3-carboxylate

Product 1

HCID 58629762HCID 58629762, compoundYield 81.8%

Procedure

2-Chloro-6-methylnicotinic acid benzyl ester (1.0 g) and 4-methoxycarbonylphenylboronic acid (722 mg) were treated in a similar manner to Step b) of Reference Example 1 to give the title compound (1.13 g).

Sources & evidence

ORD record
ord-f0389d0e97244f8f80a4185fd3c7c30a
Source dataset
uspto-grants-2012_01
Patent number
US08101774B2

Reaction notes

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