HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Vanillate → Methyl 4-hydroxy-3-iodo-5-methoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Vanillate | HCID 19844 | — |
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 4-hydroxy-3-iodo-5-methoxybenzoate | HCID 53426739 | 113.6% |
Reaction Steps
To a solution of 4-hydroxy-3-methoxybenzoic acid methyl ester (5.0 g) in tetrahydrofuran (20 mL) was added N-iodosuccinimide (6.17 g) at 0° C., and the mixture was stirred for 1 hour. The precipitated solid was filtered, washed with water, and dried to give the title compound (9.60 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101774B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-91f5d4f170584cc5abefa9ba12bcba63 |
| Source note | uspto-grants-2012_01 |