3-(3-Dimethylcarbamoyl-4-nitrophenyl)propionic acid ethyl ester → 3-(4-Amino-3-dimethylcarbamoylphenyl)propionic acid ethyl ester

関与物質

反応手順

3-(3-Dimethylcarbamoyl-4-nitrophenyl)propionic acid ethyl ester (1.52 g) was dissolved in a mixed solution of THF (tetrahydrofuran) (15 mL) and ethanol (15 mL). 7.5% (w/w) palladium-carbon (300 mg) was added thereto, followed by stirring overnight at normal pressure in hydrogen atmosphere. The reaction solution was filtered through a Celite pad and concentrated to give the title compound (0.950 g) as a pale yellow oil.

情報源と証拠