HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42333Generated: October 29, 2026
Potassium Carbonate → 3-Amino-6-(4-fluorophenyl)picolinamide
https://huagongshe.com/reaction/42333
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | 3-Amino-6-chloropyridine-2-carboxamide | HCID 10749704 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Amino-6-(4-fluorophenyl)picolinamide | HCID 59647906 | 92% |
Reaction Steps
A mixture of 3-amino-6-chloro-pyridine-2-carboxylic acid amide (2 g), potassium carbonate (3.2 g), tetrakis(triphenylphosphine) palladium (0.674 g) and 4-fluorophenylboronic acid (1.79 g) in DMF (50 mL) and water (10 mL) was heated to 120° C. for 16 hours. Solvents were removed and 1N HCl (30 ml) was added to the mixture. The resulting solid was filtered to provide 2.48 g of 3-amino-6-(4-fluorophenyl)picolinamide which was characterized by its mass spectrum as follows: MS (m/z) 232 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08536187B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-b1f82f732dc844c7962596577fe63c41 |
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| Source note | uspto-grants-2013_09 |
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