反应详情

Combined 4-cyanoindole (5 g, 35.2 mmol), ethyl-4-bromobutanoate (10.29 g, 52.8 mmol) and cesium carbonate (22.92 g, 70.3 mmol) and heated to 80° C. under argon for 1 hour. The reaction was allowed to cool and then 150 ml diethyl ether was added and the organic solution was washed with 3×150 ml H2O. Dried the organic solution over MgSO4 and evaporated the solvent. Dried on high vacuum over the weekend to afford the title compound (8.25 g) as an orange oil. δH (400 MHz, d6-DMSO). 1.13 (3H, t), 1.96-2.05 (2H, m), 2.26 (2H, t), 3.99 (2H, q), 4.29 (2H, t), 6.60 (1H, dd), 7.29 (1H, apparent t), 7.55 (1H, dd), 7.68 (1H, d), 7.90 (1H, d). MS (ES): C15H16N2O2 requires 256; found 257 (MH+).

1. temperatureto cool
2. washthe organic solution was washed with 3×150 ml H2O
3. dry with materialDried the organic solution over MgSO4
4. customevaporated the solvent
5. customDried on high vacuum over the weekend