HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 423336Generated: October 25, 2026
Sodium Carbonate → HCID 178471833, compound
https://huagongshe.com/reaction/423336
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Ethyl 3-(4-cyano-1H-indol-1-yl)propanoate | HCID 59318406 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178471833 | HCID 178471833 | 103.9% |
Reaction Steps
Ethyl 3-(4-cyano-1H-indol-1-yl)propanoate (D54) (3.44 g), NH2OH.HCl (1.97 g) and Na2CO3 (5.96 g) were dissolved in EtOH (75 ml). This mixture was heated at 50° C. overnight. A further portion of NH2OH.HCl (985 mg) was added and the mixture stirred at 70° C. overnight. The reaction mixture was then filtered and evaporated to give the title compound (4.06 g). MS (ES): C14H17N3O3 requires 275; found 276 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08101775B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-dd893dce617e4ced8e0a263297264b48 |
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| Source note | uspto-grants-2012_01 |
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