反应详情

温度

160 °C

A mixture of [2-Chloro-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-4-yl]-(2,2,2-trifluoro-ethyl)-amine (108 mg) and 3-[1,2,4]Triazol-1-yl-benzylamine (124 mg) was dissolved in NMP (1.9 mL) and treated with diisopropylethylamine (0.060 mL). The reaction mixture was sealed and heated by microwave to 160° C. for 1 h. After cooling, the reaction mixture was added dropwise to a stirred solution of water:acetonitrile (1:1). The resulting precipitate was filtered and purified by silica gel chromatography (0-10% EtOH (containing 11% NH4OH sat aq):DCM) to afford 89 mg (60% yield) of the title compound, which was characterized by its NMR and mass spectrum as follows: 1H NMR (d6-DMSO): d 4.29-4.41 (m, 2H), 4.63-4.66 (m, 2H), 7.29-7.35 (m, 2H), 7.40-7.51 (m, 2H), 7.70-7.75 (m, 3H), 7.87 (s, 1H), 8.19-8.22 (m, 2H), 8.36-8.39 (m, 2H), 8.61-8.64 (m, 1H), 9.25 (s, 1H); MS (m/z): 495.3 ([M+H]+, 100).

1. customThe reaction mixture was sealed
2. temperatureAfter cooling
3. filtrationThe resulting precipitate was filtered
4. custompurified by silica gel chromatography (0-10% EtOH (containing 11% NH4OH sat aq):DCM)