反应详情

温度

50 °C

To ethyl 3-(3-chloro-5-{5-[3-chloro-4-(propyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indol-1-yl)propanoate (D101) (120 mg, 2.5 mmol) in ethanol (10 ml) was added 2N NaOH (2 ml) and the mixture heated at 50° C. for 30 minutes. Evaporated off the ethanol and filtered off the white solid which had precipitated out of the remaining solution. Mass of title compound obtained on drying was 85 mg. δH (400 MHz, d6-DMSO) 1.03 (3H, t), 1.77-1.86 (2H, m), 2.34 (2H, t), 4.17 (2H, t), 4.35 (2H, t), 7.40 (1H, d), 7.71-7.74 (2H, m), 7.91 (1H, d), 8.15 (1H, dd), 8.20-8.21 (2H, m). MS (ES) C22H1935Cl2N3O4 requires 459; found 460 (MH+).

1. customEvaporated off the ethanol
2. filtrationfiltered off the white solid which
3. customhad precipitated out of the remaining solution