HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42342Generated: October 30, 2026
N-methyl-2-pyrrolidone → 5-Aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide
https://huagongshe.com/reaction/42342
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 5-Chloro-2-fluorobenzenesulfonyl chloride | HCID 2778273 | — |
| Reactant | 4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide | HCID 58275344 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | 5-Aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide | HCID 28716369 | — |
Reaction Steps
5-Aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide was synthesized in a manner analogous to 4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide in Example 4, using 5-chloro-2-fluorobenzene-1-sulfonyl chloride in place of 4-bromo-3-methylbenzene-1-sulfonyl chloride. In the second step NMP was used as the solvent, Pd(dppf)Cl2 alone was used as catalyst and the reaction mixture was stirred at 120° C. for 15 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08536187B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-d091dfa4a41044699fc0cce15c88e16a |
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| Source note | uspto-grants-2013_09 |
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