HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42343Generated: October 29, 2026
N-methyl-2-pyrrolidone → 3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide
https://huagongshe.com/reaction/42343
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 3-Bromo-5-(trifluoromethyl)benzenesulfonyl chloride | HCID 2778610 | — |
| Reactant | 4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide | HCID 58275344 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | 3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide | HCID 67161162 | — |
Reaction Steps
3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide was synthesized in a manner analogous to 4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide in Example 4, using 3-bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride in place of 4-bromo-3-methylbenzene-1-sulfonyl chloride. In the second step NMP was used as the solvent, Pd(dppf)Cl2 alone was used as catalyst and the reaction mixture was stirred at 150° C. for 30 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08536187B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-bc53aee8e2024ab8b13c3f5dafe5c0fa |
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| Source note | uspto-grants-2013_09 |
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