HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42344Generated: October 26, 2026
Sodium Carbonate → HCID 67162631, compound
https://huagongshe.com/reaction/42344
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Bromo-2-(trifluoromethyl)benzenesulfonyl chloride | HCID 2778608 | — |
| Reactant | 4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide | HCID 58275344 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | HCID 178476572 | HCID 178476572 | — |
| Product | HCID 67162631 | HCID 67162631 | — |
Reaction Steps
4-Aminomethyl-N-tert-butyl-2-trifluoromethyl-benzenesulfonamide was synthesized in a manner analogous to 4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide in Example 4, using 4-bromo-2-(trifluoromethyl)benzene-1-sulfonyl chloride in place of 4-bromo-3-methylbenzene-1-sulfonyl chloride. In the second step, K4-[Fe(CN)6].3H2O was used in place of Zn(CN)2, Pd(OAc)2/dppf was used as the catalyst, Na2CO3 was used as base and the reaction mixture was stirred at 110° C. with microwave irradiation for one hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08536187B2 |
|---|
| Source dataset | uspto-grants-2013_09 |
|---|
| ORD ID | ord-57362e0c918042e0b418f4e8e28291a4 |
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| Source note | uspto-grants-2013_09 |
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