HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenylboronic acid → 1-Methylethyl 4-({[4'-(trifluoromethyl)-4-biphenylyl]oxy}methyl)-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | 4-(4-Bromophenoxymethyl)piperidine-1-carboxylic acid isopropyl ester | HCID 57930300 | — |
| Product | 1-Methylethyl 4-({[4'-(trifluoromethyl)-4-biphenylyl]oxy}methyl)-1-piperidinecarboxylate | HCID 59177763 | 5.2% |
Reaction Steps
The title compound (2.2 mg, 5%) was prepared from [4-(trifluoromethyl)phenyl]boronic acid (19 mg, 0.1 mmol) and 1-methylethyl 4-{[(4-bromophenyl)oxy]methyl}-1-piperidinecarboxylate (Example 9, Step 2, 36 mg, 0.10 mmol) in a manner similar to Example 9, Step 3. LRMS (ESI), m/z 444 (M+Na).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101634B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-05990a600283407c9d3ce4e65c2c72b8 |
| Source note | uspto-grants-2012_01 |