HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Benzylcarbamoyl)benzeneboronic acid → 1-Methylethyl 4-{[(4'-{[(phenylmethyl)amino]carbonyl}-4-biphenylyl)oxy]methyl}-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Benzylcarbamoyl)benzeneboronic acid | HCID 2773243 | — |
| Reactant | 4-(4-Bromophenoxymethyl)piperidine-1-carboxylic acid isopropyl ester | HCID 57930300 | — |
| Product | 1-Methylethyl 4-{[(4'-{[(phenylmethyl)amino]carbonyl}-4-biphenylyl)oxy]methyl}-1-piperidinecarboxylate | HCID 59177812 | 15% |
Reaction Steps
The title compound (7.1 mg, 15%) was prepared from (4-{[(phenylmethyl)amino]carbonyl}phenyl)boronic acid (25.5 mg, 0.1 mmol) and 1-methylethyl 4-{[(4-bromophenyl)oxy]methyl}-1-piperidinecarboxylate (Example 9, Step 2, 36 mg, 0.10 mmol) in a manner similar to Example 9, Step 3. LRMS (ESI), m/z 487 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101634B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-600d89ab76a14d29a634d6bc8d37ea2a |
| Source note | uspto-grants-2012_01 |