HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-(Pyrrolidine-1-carbonyl)phenyl)boronic acid → 1-Methylethyl 4-({[4'-(1-pyrrolidinylcarbonyl)-4-biphenylyl]oxy}methyl)-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-(Pyrrolidine-1-carbonyl)phenyl)boronic acid | HCID 2773571 | — |
| Reactant | 4-(4-Bromophenoxymethyl)piperidine-1-carboxylic acid isopropyl ester | HCID 57930300 | — |
| Product | 1-Methylethyl 4-({[4'-(1-pyrrolidinylcarbonyl)-4-biphenylyl]oxy}methyl)-1-piperidinecarboxylate | HCID 59177765 | 19.1% |
Reaction Steps
The title compound (8.6 mg, 19%) was prepared from [4-(1-pyrrolidinylcarbonyl)phenyl]boronic acid (21.9 mg, 0.1 mmol) and 1-methylethyl 4-{[(4-bromophenyl)oxy]methyl}-1-piperidinecarboxylate (Example 9, Step 2, 36 mg, 0.10 mmol) in a manner similar to Example 9, Step 3. LRMS (ESI), m/z 451 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101634B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-04dab5d16a9440d49c33f8e5e7b84302 |
| Source note | uspto-grants-2012_01 |