HRID42348
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 120 °C
PROCEDURE
实验过程
A mixture of 2-chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-4-ol (377 mg), (R)-4-(1-aminoethyl)-N-tert-butylbenzenesulfonamide (456 mg) and DIEA (243 ml) in NMP (4 ml) was heated at 120° C. overnight. The reaction mixture was then added to H2O/ACN (9:1) with vigorous stirring and extracted with EtOAc. The organic layer was dried and concentrated to give 1.1 g crude (R)—N-tert-butyl-4-(1-(6-(4 fluorophenyl)-4-hydroxypyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide as golden brown oil, which was used in the next step without purification.
WORKUP
后处理
- extractionextracted with EtOAc
- customThe organic layer was dried
- concentrationconcentrated