Sodium Carbonate → HCID 59177823, compound

Participants

Reaction Steps

The title compound (29 mg, 27%) was prepared as a white solid from {4-[(dimethylamino)carbonyl]phenyl}boronic acid (39 mg, 0.2 mmol), 1-methylethyl 4-{[(4-bromophenyl)oxy]methyl}-1-piperidinecarboxylate (prepared as in Example 9, Step 2, 71 mg, 0.2 mmol), Pd(PPh3)2Cl2 (50 mg, 0.07 mmol), 2M Na2CO3 (1 mL) and DME (1 mL) in a manner similar to Example 21, Step 3, and worked up in a manner similar to Example 9, Step 3. 1H NMR (400 MHz, CDCl3): δ 7.63-7.42 (m, 6H), 6.96 (d, 2H, J=8.8 Hz), 4.98-4.81 (m, 1H), 4.20 (bs, 2H), 3.84 (d, 2H, J=6.4 Hz), 3.13 (s, 3H), 3.04 (s, 3H), 2.84-2.74 (m, 2H), 2.08-1.92 (m, 1H), 1.90-1.80 (m, 2H), 1.37-1.14 (m, 8H); LRMS (ESI), m/z 425 (M+H).

Provenance & Evidence