4-Aminocarbonylphenylboronic acid → HCID 59177819, compound

Participants

Reaction Steps

The title compound (15 mg, 15%) was prepared from [4-(aminocarbonyl)phenyl]boronic acid (33 mg, 0.2 mmol) and 1-methylethyl 4-{[(4-bromophenyl)oxy]methyl}-1-piperidinecarboxylate (prepared as in Example 9, Step 2, 71 mg, 0.2 mmol) in a manner similar to Example 21, Step 3 and worked up in a manner similar to Example 9, Step 3. 1H NMR (400 MHz, CDCl3): δ 7.86 (d, 2H, J=8.1 Hz), 7.63 (d, 2H, J=8.1 Hz), 7.55 (d, 2H, J=8.8 Hz), 6.97 (d, 2H, J=8.9 Hz), 6.09 (s, 2H), 4.99-4.86 (m, 1H), 4.28-4.14 (m, 2H), 3.85 (d, 2H, J=6.4 Hz), 2.84-2.74 (m, 2H), 2.05-1.95 (m, 1H), 1.90-1.80 (m, 2H), 1.34-1.18 (m, 8H); LRMS (ESI), m/z 419 (M+Na).

Provenance & Evidence