Isopropyl chloroformate → HCID 24994034, compound

Participants

Reaction Steps

The title compound (151 mg, 98%) was prepared as a white solid 5-[4-(methylsulfonyl)phenyl]-2-[(4-piperidinylmethyl)oxy]pyridine dihydrochloride (0.15 g, 0.36 mmol), diisopropylethylamine (0.26 mL, 1.43 mmol), and isopropyl chloroformate (1.0M in toluene, 0.40 mL, 0.40 mmol) in a manner similar to Example 66, Step 2. 1H NMR (400 MHz, CD3OD): δ 8.46 (d, 1H, J=2.4 Hz), 8.10-8.00 (m, 3H), 7.86 (d, 2H, J=8.3 Hz), 6.92 (d, 1H, J=8.5 Hz), 4.90-4.80 (m, 1H), 4.21 (d, 2H, J=6.3 Hz), 4.20-4.10 (m, 2H), 3.14 (s, 3H), 2.90-2.75 (m, 2H), 2.10-2.00 (m, 1H), 1.90-1.80 (m, 2H), 1.35-1.20 (m, 8H); LRMS (ESI), m/z 433 (M+H).

Provenance & Evidence