Potassium Carbonate → HCID 24994332, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-[4-(methylsulfonyl)phenyl]-2-[(4-piperidinylmethyl)oxy]pyridine dihydrochloride (Example 71, Step 1, 0.16 g, 0.38 mmol), 2-chloro-5-ethylpyrimidine (0.1 mL, 0.76 mmol) and K2CO3 (0.26 g, 1.91 mmol) in CH3CN (3 mL) was degassed, purged with N2 and heated at 80° C. overnight. After more CH3CN (2 mL) was added, the reaction mixture was heated at 80° C. for two days. The mixture was allowed to cool to ambient temperature, water was added and the mixture was extracted with EtOAc. The combined organic extract was washed with brine, dried over Na2SO4, filtered, and the filtrate was concentrated to give the crude product as a light yellow solid. The crude product was purified by chromatography on a silica gel column eluted with 2:5 EtOAc/CH2Cl2 to give 0.114 g (66%) of the title compound as a white solid. 1H NMR (400 MHz, CDCl3): δ 8.39 (d, 1H, J=2.5 Hz), 8.20 (bs, 2H), 8.01 (d, 2H, J=8.3 Hz), 7.82 (dd, 1H, Ja=8.7 Hz, Jb=2.6 Hz), 7.70 (d, 2H, J=8.3 Hz), 6.85 (d, 1H, J=8.5 Hz), 4.81 (bs, 2H), 4.24 (d, 2H, J=6.3 Hz), 3.08 (s, 3H), 3.05-2.85 (m, 2H), 2.55-2.40 (m, 2H), 2.20-2.05 (m, 1H), 2.00-1.90 (m, 2H), 1.45-1.30 (m, 2H), 1.19 (t, 3H, J=7.5 Hz); LRMS (ESI), m/z 453 (M+H).

Provenance & Evidence