反应详情

1,1-Dimethylethyl 4-[({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate (prepared as in Example 73, 0.132 g, 0.30 mmol) was dissolved in CH2Cl2 (9 mL). TFA (0.30 mL) was added to this solution and the mixture was stirred at ambient temperature overnight. The excess TFA and CH2Cl2 were removed under reduced pressure. The residue was redissolved in CH2Cl2 (9 mL). The solution was cooled to 0° C. in an ice bath, and diisopropylethylamine (1.5 mL) was added, followed by addition of isopropyl chloroformate (1.0M in toluene, 0.36 mL, 0.36 mmol). The reaction mixture was allowed to warm to ambient temperature, and stirred for 2 h, then diluted with EtOAc, washed with water and brine, dried over Na2SO4, filtered, and the filtrate was concentrated to give the crude product as a light yellow solid. The crude product was purified by chromatography on a silica gel column eluted with 9:4 EtOAc/hexane to give 0.12 g (93%) of the title compound as a white solid. 1H NMR (400 MHz, CDCl3): δ 8.40 (d, 1H, J=2.7 Hz), 8.14 (d, 2H, J=8.3 Hz), 8.01 (d, 2H, J=8.6 Hz), 7.74 (d, 1H, J=8.8 Hz), 7.35-7.25 (m, 1H), 4.92 (septet, 1H, J=6.2 Hz), 4.23 (bs, 2H), 3.92 (d, 2H, J=6.3 Hz), 3.08 (s, 3H), 2.85-2.70 (m, 2H), 2.10-1.95 (m, 1H), 1.90-1.80 (m, 2H), 1.40-1.20 (m, 8H); LRMS (APCI), m/z 433 (M+H).

1. customThe excess TFA and CH2Cl2 were removed under reduced pressure
2. dissolutionThe residue was redissolved in CH2Cl2 (9 mL)
3. temperatureThe solution was cooled to 0° C. in an ice bath
4. additiondiisopropylethylamine (1.5 mL) was added
5. temperatureto warm to ambient temperature
6. stirringstirred for 2 h
7. washwashed with water and brine
8. dry with materialdried over Na2SO4
9. filtrationfiltered
10. concentrationthe filtrate was concentrated
11. customto give the crude product as a light yellow solid
12. customThe crude product was purified by chromatography on a silica gel column
13. washeluted with 9:4 EtOAc/hexane