Hydrochloric Acid → HCID 66673118, compound

Participants

Reaction Steps

1-Methylethyl-4-{[(6-{4-[(ethyloxy)carbonyl]phenyl}-3-pyridinyl)oxy]methyl}-1-piperidinecarboxylate (0.3 g, 0.70 mmol) was added to a solution of NaOH (0.06 g, 1.4 mmol) in ethanol (10 mL). The reaction mixture was stirred overnight, neutralized with 1N HCl and freeze-dried to give 4-(5-{[(1-{[(1-methylethyl)oxy]carbonyl}-4-piperidinyl)methyl]oxy}-2-pyridinyl)benzoic acid, which was used without further purification. 1H NMR (400 MHz, DMSO-d6): δ 8.38 (d, 1H, J=3.0 Hz), 8.12 (d, 2H, J=8.7 Hz), 8.01-7.97 (m, 3H), 7.53-7.49 (m, 1H), 4.77-4.71 (m, 1H), 4.04-3.94 (m, 4H), 2.07 (bs, 3H), 1.80-1.72 (m, 2H), 1.19-1.13 (m, 8H); LRMS (ESI), m/z 399 (M+H).

Provenance & Evidence