Triphenylphosphine → HCID 24992097, compound

Participants

Reaction Steps

The title compound (169 mg, 45%) was prepared as a white solid from 1,1-dimethylethyl (2-{[(4′-hydroxy-4-biphenylyl)sulfonyl]amino}ethyl)carbamate (246 mg, 0.63 mmol), {1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}methanol (prepared as in Example 20, Step 3, 214 mg, 0.95 mmol) and Ph3P (249 mg, 0.95 mmol) in THF (5 mL) followed by diisopropyl azodicarboxylate (0.187 mL, 0.95 mmol) in a manner similar to Example 1, Step 2. 1H NMR (400 MHz, DMSO-d6) δ 7.84-7.72 (m, 4H), 7.70-7.60 (m, 3H), 7.03 (d, 2H, J=8.8 Hz), 6.76 (t, 1H, J=5.4 Hz), 4.03-3.91 (m, 2H), 3.90 (d, 2H, J=6.4 Hz), 3.15-3.05 (m, 2H), 2.98-2.88 (m, 2H), 2.83-2.67 (m, 3H), 2.06-1.94 (m, 1H), 1.89-1.79 (m, 2H), 1.38-1.24 (m, 11H), 1.14 (d, 6H, J=7.0 Hz); LRMS (ESI), m/z 600 (M+H).

Provenance & Evidence