Sodium Carbonate → HCID 66673129, compound

Participants

Reaction Steps

1-Methylethyl 4-[({6-[4-(hydroxymethyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate (208 mg, 77%) was prepared as a white solid from 4-(hydroxy methyl)phenylboronic acid (130 mg, 0.84 mmol), 1-methylethyl 4-{[(6-bromo-3-pyridinyl)oxy]methyl}-1-piperidinecarboxylate (prepared as in Example 81, Step 1, 250 mg, 0.70 mmol), Pd(PPh3)2Cl2 (50 mg, 0.07 mmol), 2M Na2CO3 (4 mL) and DME (4 mL) in a manner similar to Example 21, Step 3. 1H NMR (400 MHz, CDCl3): δ 8.37 (bs, 1H), 7.94 (d, 2H, J=7.9 Hz), 7.70 (d, 1H, J=8.6 Hz), 7.46 (d, 2H, J=8.1 Hz), 7.45-7.30 (bs, 1H), 4.91 (septet, 1H, J=6.2 Hz), 4.74 (s, 2H), 4.21 (bs, 2H), 3.90 (d, 2H, J=6.2 Hz), 2.85-2.70 (m, 2H), 2.10-1.95 (m, 1H), 1.90-1.80 (m, 2H), 1.35-1.20 (m, 8H); LRMS (ESI), m/z 385 (M+H).

Provenance & Evidence