HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → HCID 178518402, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 3-Amino-6-(4-fluorophenyl)picolinamide | HCID 59647906 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 178518402 | HCID 178518402 | — |
Reaction Steps
A solution of 3-amino-6-(4-fluorophenyl)picolinamide (2.48 g) and triphosgene in 1,4-dioxane (50 mL) was heated to 100° C. for 1 hour. Cooling and filtration provided 2.2 g of 6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine-2,4-diol which was characterized by its mass spectrum as follows: MS (m/z) 258 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536187B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-dfeb68a0d1b54599b1d628b0e80a357a |
| Source note | uspto-grants-2013_09 |