HCID 59177824, compound → HCID 66673312, compound

Participants

Reaction Steps

(±)-Phenylmethyl 4-[1-({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)ethyl]-1-piperidinecarboxylate (Example 139, 0.37 g, 0.75 mmol) was dissolved in MeOH (10 mL) and THF (5 mL). 10% of Pd/C (40 mg, Degussa type) was added, and the mixture was placed under an atmosphere of hydrogen using a H2 balloon at ambient temperature for 4 h. The mixture was filtered through Celite® and the filtrate was concentrated to give 0.27 g (100%) of (±)-2-[4-(methylsulfonyl)phenyl]-5-{[1-(4-piperidinyl)ethyl]oxy}pyridine as a viscous colorless oil. 1H NMR (400 MHz, CDCl3): δ 8.38 (d, 1H, J=2.9 Hz), 8.12 (d, 2H, J=8.5 Hz), 8.00 (d, 2H, J=8.3 Hz), 7.72 (d, 1H, J=8.8 Hz), 7.30-7.25 (m, 1H), 4.30-4.20 (m, 1H), 3.20-3.10 (m, 2H), 3.08 (s, 3H), 2.70-2.60 (m, 2H), 1.95-1.65 (m, 3H), 1.45-1.25 (m, 5H); LRMS (ESI), m/z 361 (M+H).

Provenance & Evidence