Carbon Dioxide → HCID 59177825, compound

Participants

Reaction Steps

The racemic 1-methylethyl 4-[1-({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)ethyl]-1-piperidinecarboxylate (prepared as in Example 140) was subjected to Chiral HPLC [column: AS-H, column mobile phase: 80% CO2: 20% MeOH (2 mL/min), pressure 140 bar, temperature 40° C., 280 nm] analysis and then separated to give two (R and S) enantiomers. The title compound was isolated as a white foam with Tr of 13.23 min (second eluting peak). The (S) absolute stereochemistry was assigned by Ab initio VCD analysis.

Provenance & Evidence