HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → [4-Bromo-2-(methanesulfonyl)phenyl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 4-Bromo-2-(methylsulfonyl)benzaldehyde | HCID 2761076 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | [4-Bromo-2-(methanesulfonyl)phenyl]methanol | HCID 59251623 | 71.5% |
Reaction Steps
To a solution of 4-bromo-2-methansulfonyl-benzaldehyde (1.0 g, 3.88 mmol) in EtOH (11 mL)/THF (2.5 mL) was added NaBH4 (1.29 g, 34.2 mmol) in three portions. The reaction was carefully quenched with water and the product was extracted with EtOAc, dried (Na2SO4), and purified by silica gel chromatography to give 735 mg of (4-bromo-2-methansulfonyl-phenyl)-methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536187B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-3d88b6e748454650a9020d7c708611a7 |
| Source note | uspto-grants-2013_09 |